An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation.

An Important Role of CDK Inhibitor p18 in Modulating Antigen Receptor-Mediated T Cell Proliferation

CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.

Mammary epithelia are composed of luminal and myoepithelial/basal cells whose neoplastic transformations lead to distinct types of breast cancers with diverse clinical features. We report that mice deficient for the CDK4/6 inhibitor p18(Ink4c) spontaneously develop ER-positive luminal tumors at a high penetrance. Ink4c deletion stimulates luminal progenitor cell proliferation at pubertal age an...

The negative cell cycle regulators, p27Kip1, p18Ink4c, and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate

Adult human pancreatic β-cells are primarily quiescent (G0) yet the mechanisms controlling their quiescence are poorly understood. Here, we demonstrate, by immunofluorescence and confocal microscopy, abundant levels of the critical negative cell cycle regulators, p27(Kip1) and p18(Ink4c), 2 key members of cyclin-dependent kinase (CDK) inhibitor family, and glycogen synthase kinase-3 (GSK-3), a ...

A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency.

UNLABELLED Gammaherpesviruses (GHVs) carry homologs of cellular genes, including those encoding a viral cyclin that promotes reactivation from latent infection. The viral cyclin has reduced sensitivity to host cyclin-dependent kinase inhibitors in vitro; however, the in vivo significance of this is unclear. Here, we tested the genetic requirement for the viral cyclin in mice that lack the host ...

Contrasting behavior of the p18 and p16 tumor suppressors in both replicative and oncogene-induced senescence

Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract The CDK inhibitors, p18 INK4c and p16 INK4a , both have the credentials of tumor suppressors in human cancers and mouse models. For p16 INK4a , the underlying rationale is its role in senescence but the selective force for inactivation of p18 INK4c in incipient cancer cells is less cle...